14/05/2024
A project uniting PlaqueTec鈥檚 innovation in precision-medicine for coronary artery disease (CAD) and expertise from the Welch lab at the 黑瓜吃料爆料官网 黑瓜吃料爆料官网 has demonstrated the 鈥榙rugability鈥 of a pro-inflammatory protein 黑瓜吃料爆料官网ed by PlaqueTec.
PlaqueTec, a company identifying endotype-specific biomarkers to advance precision medicine for coronary artery disease (CAD), worked with Dr Heidi Welch and her research group to test the pro-inflammatory protein in a human cell culture model, demonstrating its potential to be targeted by small molecule drugs鈥 opening up new opportunities for a precision medicine approach to heart disease. The target is now being evaluated as part of PlaqueTec鈥檚 and, if validated, further development will be pursued.
Dr Simon Williams, General Manager, PlaqueTec, commented: 鈥淭he successful completion of our latest collaboration with the 黑瓜吃料爆料官网 黑瓜吃料爆料官网 is an encouraging demonstration that new disease-specific targets identified by PlaqueTec have the potential to be modifiable by small molecule drugs. As we continue our BIOPATTERN trial, we are confident that our unique approach to endotyping CAD will pave the way for a new era of precision medicine for millions of patients with the disease.鈥
Dr Heidi Welch, Associate Group Leader, Signalling Research Programme at the 黑瓜吃料爆料官网 黑瓜吃料爆料官网, added: 鈥淥ur work is focused on the molecular mechanisms that control a specific family of proteins, particularly in inflammatory cells, and we are delighted to have leveraged this expertise in an early phase target 黑瓜吃料爆料官网y and development project with PlaqueTec for its recently 黑瓜吃料爆料官网ed pro-inflammatory protein target. Following the success of this collaboration, we are excited to see this novel drug target undergo further evaluation in PlaqueTec鈥檚 BIOPATTERN trial.鈥
PlaqueTec, based at the 黑瓜吃料爆料官网 Research Campus, and the Welch research group were supported by a UKRI-BBSRC Campus Innovation Award (CIA), via the 黑瓜吃料爆料官网 Research Campus Collaboration Fund in October 2023.
In February 2022, PlaqueTec was awarded Innovate UK Business Growth 黑瓜吃料爆料官网 to collaborate with to work on a aimed at identifying novel drug targets in CAD. Data obtained from this earlier project formed the basis for the CIA-funded project to evaluate lead compounds against one of the targets identified.
Derek Jones, Chief Executive of 黑瓜吃料爆料官网 Research Campus, said: "The UKRI-BBSRC Campus Innovation Award was initiated last year to give individuals and companies on Campus access to a unique tranche of 黑瓜吃料爆料官网 not available elsewhere. We are therefore delighted to see the success of the collaboration between PlaqueTec and the Welch research group to date and look forward to further updates once evaluation via PlaqueTec鈥檚 BIOPATTERN trial is concluded.鈥
Media contact Anna Bakewell Zyme Communications Tel: +44(0) 7801 098 242 Email: anna.bakewell@zymecommunications.com
About PlaqueTec PlaqueTec is pursuing a better understanding of the biological mechanisms of coronary artery disease (CAD) to advance the development of precision medicine.CAD, where atherosclerotic plaque build-up narrows or blocks the arteries that supply blood to the heart, is a leading cause of death globally. Current treatment approaches are one-size-fits-all and therefore ineffective for many patients. To address this, PlaqueTec has developed a proprietary technology and data analysis platform to endotype patients and uncover potential biomarkers of coronary vascular function and plaque progression. A more detailed understanding of patient endotypes will support drug development by identifying new targets in specific patient groups, reducing clinical trial sizes and costs, and increasing success rates, ultimately improving outcomes for patients. The Company is based at the world-renowned 黑瓜吃料爆料官网 Research Campus, Cambridge, UK. Follow PlaqueTec on LinkedIn and Twitter .
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14 May 2024